 Mangosteen
Fruit
The
mangosteen tree is a small, slow growing tropical
evergreen with leathery, glabrous leaves up to 10 inches
long. Fruits are borne on lateral branches. They have a
thick rind, which encloses 5 to 7 fleshy segments, in
which the seeds are imbedded. The pulp, the only part
consumed, has excellent flavor, proclaimed by many as the
best among tropical fruits. Often two crops per year
mature, one in the autumn, and one in early summer. The
proportion of edible pulp is rather small. The trees often
bear sparingly. Culture is limited except in tropical
India and the East Indies. The mangosteen is
ultra-tropical. It cannot tolerate temperatures below 40º
F (4.44º C), nor above 100º F (37.78º C). Nursery
seedlings are killed at 45º F (7.22º C). It is
limited in Malaya to elevations below 1,500 ft (450 m). In
Madras it grows from 250 to 5,000 ft (76-1,500 m) above
sea-level. Attempts to establish it north of 200 latitude
have all failed.
Research From The National
Library of Medicine
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Gamma-mangostin
shifts rightward the dose/response curve for 5-HT
induced aorta contraction without affecting
contractile responses to KCl, phenylephrine or
histamine
Chairungsrilerd 1998
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Salmonella
is inhibited and PMN phagocytes stimulated by
polysaccharides from mangosteen pericarp
Chanarat 1997
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Histamine &
serotonin induced aorta contraction was inhibited
by a methanolic extract of Garcinia mangostana
fruit hulls. Alpha-Mangostin is a competitive
histamine H1 receptor antagonist. Gamma-mangostin
is a competitive 5-HT2A receptor antagonist
Furukawa 1997
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Anti-fungal
activity of xanthones and mangostin from Garcinia
mangostana fruit hulls
Gopalakrishnan 1997
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Alpha-mangostin
and gamma-mangostin appear to be histaminergic and
a serotonergic receptor blocking agents,
respectively
Chairungsrilerd 1996
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HIV-1
protease is inhibited by Garcinia mangostana
ethanol extract, due to mangostin (IC50 = 5.1
microM) and gamma-mangostin (IC50 = 4.8 microM)
Chen 1996 |
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Alpha-mangostin,
a xanthone derivative from G. mangostana, inhibits
methicillin-resistant Staphylococcus aureus, MIC =
1.6 -12.5 micrograms/ml. Rubraxanthone from G.
dioica is more active, MIC = 0.3-1.2 micrograms/ml
Iinuma 1996 |
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Low density
lipoprotein oxidation is inhibited by mangostin
dose dependently at 5 - 50 microM
Williams 1995
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"Antimicrobial activities of Garcinia mangostana "
(no abstract)
Sundaram 1983
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Animal Studies
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Gamma-mangostin
from Garcinia mangostana fruit hull injected
(10-40 nmol/mouse) inhibited 5FMT induced
head-twitch response and inhibits accumulation of
inositol phosphates indicating it to be a 5-HT2A
receptor antagonist
Chairungsrilerd 1998
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"Effect of
mangostin, a xanthone from Garcinia mangostana
Linn. in immunopathological & inflammatory
reactions " (no abstract)
Gopalakrishnan 1980
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